Author

Craig G. Rogers

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Jul 2026

Abstract A079: Structure-guided discovery of first-in-class TRIB2 small-molecule inhibitors for therapy-resistant neuroendocrine prostate cancer

These findings establish TRIB2 as a druggable vulnerability in enzalutamide-resistant and NE prostate tumors despite the inherent challenges of targeting pseudokinases.

J. Monga, Sang-Yoon Lee, Deepak Rohila et al. · Clinical Cancer Research · 0 citations