Discovery of potent, selective and insurmountable MRGPRX2 antagonists for mast cell-driven disorders 2308475
Lead antagonists demonstrated potent and insurmountable inhibition of MRGPRX2-mediated responses across all cellular models and were active against all MRGPRX2 agonists tested, highlighting the therapeutic promise of those insurmountable MRGPRX2 antagonists for the treatment of mast cell—driven disorders.