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Cristiana Griffante

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Jul 2026

Discovery of potent, selective and insurmountable MRGPRX2 antagonists for mast cell-driven disorders 2308475

Lead antagonists demonstrated potent and insurmountable inhibition of MRGPRX2-mediated responses across all cellular models and were active against all MRGPRX2 agonists tested, highlighting the therapeutic promise of those insurmountable MRGPRX2 antagonists for the treatment of mast cell—driven disorders.

Yves A Millet, J. Close, Wei Hu et al. · 0 citations

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