Review
Open access
Aug 2026
Aquaporin dysfunction and impaired brain interstitial fluid clearance in Alzheimer’s disease – an integrative review
AQP4 knockout consistently exacerbates Aβ pathology and cognitive deficits, with the abnormal distribution of AQP4 within the astrocyte being sufficient to impair clearance, and data highlight the critical importance of polarized expression versus bulk expression levels.
M. Manescu, Teodora-Nicoleta Minca, I. Pirici et al.
· Frontiers in Cellular Neuros... · 0 citations