Open access
Aug 2026
Vimentin remodeling in response to oxidants and electrophiles is modulated by pH
Vimentin is critical for cell mechanosensing, cytoskeletal cross-talk, and stress responses and is finely tuned by posttranslational modifications. Vimentin single cysteine, C328, is a modification hotspot, essential for filament remodeling by oxidants and electrophiles. With a pKa near physiological pH, C328 reactivit...
Alma E. Martínez, Paula Martínez-Cenalmor, Patricia González-Jiménez et al.
· Science Advances · 1 citation