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Crystal R. Archer

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Open access Sep 2026

Phosphorylation of the Kv7.4 B helix reorganizes calmodulin interactions and reduces PIP2 binding

Voltage-gated Kv7 (KCNQ, M-type) potassium channels regulate cellular excitability through interactions with phosphatidylinositol 4,5-bisphosphate (PIP2) and calmodulin (CaM). The distal B helix of Kv7.2-5 channels contains a conserved protein kinase C (PKC) phosphorylation site, suggesting that phosphorylation may reg...

Phuc Phan, Courage Okose, D. Sapkota et al. · 0 citations

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