Cui-Cui Chang

GSC State Plasticity Drives Therapeutic Resistance and Recurrence in Glioblastoma

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, and treatment failure is closely linked to the presence of GBM stem cells (GSCs). Rather than representing a fixed marker-defined state, GSC identity is better understood as a dynamic and reversible stem-like state. GBM cells exhibit transcription...