Aug 2026
Di(2-ethylhexyl) phthalate and Mono(2-ethylhexyl) phthalate upregulate PPARG and induce metabolic reprogramming in hepatocellular carcinoma cells: a pan-cancer and metabolomics study.
Findings support a functional contribution of PPARG to DEHP/MEHP-associated lipid accumulation, potentially involving a DGAT2/PLIN2-related lipid-storage program, and provide mechanistic clues to phthalate-associated metabolic dysregulation in liver cancer cells.
Yuxing Liao, Hui-Qiong Liang, Hongmei Huang et al.
· Food and Chemical Toxicology · 0 citations