Sep 2026
A mitochondria-targeted supramolecular nanoplatform overcomes cisplatin resistance via self-amplified ferroptosis.
An upregulated GPX4 level of tumor cells with enhanced antioxidant defense systems accounts substantially for cisplatin resistance, but on the other hand, offers a unique therapeutic strategy due to the improved sensitivity of tumor cells to ferroptosis. Effective ferroptosis induction remains a challenge owing to insu...
Ying Liu, Zong-Tao Zhou, Wei Ma et al.
· International journal of pha... · 0 citations