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Cynthia Weigel

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Open access Aug 2026

Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism

Obesity increases circulating levels of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P). Here, we identify adipocyte-expressed sphingosine kinase 2 (SPHK2), an enzyme that produces S1P, as a regulator of adipose tissue browning. Mice with adipocyte-specific deletion of Sphk2 were protected from West...

R. Brown, Cynthia Weigel, Yadu Vijayan et al. · 0 citations

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