Author

Cyrus Y. Jin

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Open access Sep 2026

A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer.

Combined genome-wide CRISPR knockout screening with base editor tiling screens at amino acid resolution reveal molecular rules governing HUWE1 phospho-degron recognition and identify a regulatory gate controlling substrate engagement and illustrate a generalizable strategy for resolving degradation mechanisms of undrug...

Keita Masuzawa, Kevin D. Dong, Calvin XiaoYang Hu et al. · Genes & Development · 0 citations

Open access Aug 2026

DCAF11-dependent molecular glue degrader activated by glutathionylation

It is established that metabolically activated compounds can redirect E3 ligase function, thereby expanding the scope of targeted protein degradation and chemically induced proximity.

Hojong Yoon, F. Wachter, Katharine A. Barrett et al. · Nature · 1 citation