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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

D. Bhowmik

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Book Open access Aug 2026

CAHS: Context-Aware Homology Search

Protein homology search is foundational to bioinformatics: it supports annotation transfer, structure/function inference, and evolutionary analysis over rapidly expanding sequence repositories (e.g., UniProtKB). Profile hidden Markov models (pHMMs), as implemented in HMMER, remain the most widely trusted approach becau...

Swethasree Bhattaram, D. Bhowmik, Ramakrishnan Kannan · 0 citations
Book Open access Aug 2026

CAHS: Context-Aware Homology Search

CAHS (Context-Aware Homology Search), a lightweight query-time adapter for pHMM search that incorporates learned and biologically motivated signals without changing HMMER's downstream search pipeline or its calibrated E-value reporting, illustrates a practical AI-for-science design pattern.

Swethasree Bhattaram, D. Bhowmik, Ramakrishnan Kannan · 0 citations

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