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Open access Sep 2026

Blarcamesine improves EEG biomarkers of cortical dysfunction in a mouse model of fragile X syndrome

Background Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism spectrum disorder. Previous studies in the Fmr1 knockout (KO) mouse model of FXS and affected individuals have identified common electroencephalographic (EEG) abnormalities, which constitute biomarkers of cortica...

Carrie Jonak, Samantha A. Assad, D. Binder et al. · 0 citations
Open access Sep 2026

Atlas-Based Electrical Source Imaging for Mouse EEG: Application to an Fmr1 Knockout Model.

Electrical source imaging (ESI) reconstructs where in the brain a scalp EEG signal arises. It is routine in humans but unestablished in the mouse, whose brain is some 3,000 times smaller where it is not obvious that a sparse array can separate one region from another. We built an atlas-based ESI pipeline for 30-channel...

Alex D. Edmondson, Andrew D. Gaulden, Richard K. Lacher et al. · 0 citations

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