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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

D. Bogunovic

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Open access Oct 2026

Cross-source proteogenomic profiling of human microglia reveals a conserved core membrane protein and HERV signature

Microglia are essential immune cells of the brain parenchyma which are responsible for maintaining homeostasis and responding to brain injury. When activated, they induce immune signaling and become phagocytic. In the context of neurodegenerative diseases, they exhibit both pro- and anti-inflammatory properties. Human...

Hoi-Tong Wong, C. Gleason, Andrew Boylan et al. · 0 citations
Open access Jul 2026

Derivation of Mesenchymal Stem Cells from Induced Pluripotent Stem Cells and Their Application in Genetic Disease Modeling 2307485

This platform enables mechanistic studies of thymic stromal dysfunction and advances understanding of immune deficits in these disorders and reveals disease-specific mesenchymal defects underlying thymic abnormalities in congenital syndromes.

Giuseppe Sangiorgio, Francesca Pala, Kayla Amini et al. · 0 citations
Open access Jul 2026

Linking zygosity and allelic balance to phenotype with programmable heterozygous editing and allele-specific single-cell RNA sequencing 2307550

An innovative CRISPR-based editing system in primary human T cells is harnessed to engineer heterozygous variants across CARD11, a key regulator of immune signaling, in which heterozygous variants cause diverse IEI with variable penetrance.

Zachary H. Walsh, C. Frangieh, Shudipto Wahed et al. · 0 citations

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