Atherosclerosis is a chronic immune–inflammatory disease of the arterial wall in which antigen-presenting cells (dendritic cells, macrophages and B cells) present locally generated antigens, such as oxidized low-density lipoprotein, to plaque-infiltrating T cells. Full T-cell activation requires costimulation through t...
A. Blagov, Alexey Vatlin, D. Borodko et al.· International Journal of Mol...· 0 citations
BACKGROUND
Mitochondria play a key role in the regulation of inflammatory processes. It is well established that mitochondria contain their own mitochondrial DNA (mtDNA), which displays a substantially higher frequency of polymorphisms compared to the nuclear genome. To maintain mitochondrial functionality, cells emplo...
A. D. Zhuravlev, N. Nikiforov, S. Verkhova et al.· Frontiers in Bioscience· 0 citations
This narrative review summarizes current data on the role of desialylation of low-density lipoproteins (LDL) as a key initiating mechanism of atherogenesis that precedes oxidative modification. The structural and functional significance of sialic acid in apolipoprotein B-100 is considered, and the enzymes of the sialid...
Tatyana I. Kovyanova, V. P. Karagodin, D. Borodko et al.· Biomolecules· 0 citations
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality worldwide, driven by complex interactions among dyslipidemia, chronic inflammation, insulin resistance, endothelial dysfunction, and gut microbiome-derived metabolites. This review synthesizes mechanistic and clinical ev...
Tatyana I. Kovyanova, M. Nerush, V. P. Karagodin et al.· Biomedicines· 0 citations
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