Author

D. Braun

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Review Open access Sep 2026

Reviving cancer vaccines in renal cell carcinoma: a new chapter in immunotherapy for kidney cancer

Renal cell carcinoma (RCC) remains one of the most immunologically responsive solid tumors, yet durable benefit from immune checkpoint inhibitors (ICIs) is achieved in only a subset of patients. Although ICIs are conventionally thought to primarily act by reinvigoration and expanding preexisting antitumor T-cell respon...

F. Scallo, J. Ishizuka, D. Braun · Immuno-Oncology Technology · 0 citations

Open access Sep 2026

56 Identification and Prioritization of Human Endogenous Retrovirus–Derived Antigens for mRNA Vaccine Development in Renal Cell Carcinoma

Abstract Background Immune checkpoint inhibitors improve outcomes in clear cell renal cell carcinoma (ccRCC), yet most patients do not achieve durable responses due in part to insufficient tumor antigenicity. While neoantigen vaccines have shown promising early-phase results in ccRCC, their patient-specific design limi...

F. Scallo, A. Dighe, Josephine Burdekin et al. · The Oncologist · 0 citations

Jul 2026

Tertiary lymphoid structures harbour stem-like tumour-specific T cells

Tertiary lymphoid structures are reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies, and are found to be reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immune pressure.

Alexander B. Afeyan, Adi Nagler, Chloe R. Tu et al. · Nature · 2 citations