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D. Calabrese

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Open access Aug 2026

Serum HBsAg cannot distinguish cccDNA activity from integrated HBV DNA expression in chronic hepatitis B virus infection.

BACKGROUND & AIMS HBsAg is currently used as the key serum biomarker to define functional cure of chronic hepatitis B (CHB). Declining HBsAg is often interpreted as evidence of cccDNA elimination or durable transcriptional silencing. However, HBsAg can also be produced from transcriptionally active HBV DNA integrated i...

A. Suslov, M. Matter, D. Calabrese et al. · 0 citations
Open access Jul 2026

CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates a β-thalassemia model

The results suggest that this approach may overcome the reliance on busulfan or other myeloablative conditioning regimens with their associated morbidities, and by enabling toxin-free conditioning and in vivo selection of edited cells, may facilitate clinical implementation of these highly valuable genetic therapies.

Romina Marone, Rosalba Lepore, K. Paschoudi et al. · 0 citations

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