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Open access Oct 2026

Multi-omics profiling identifies inflammation metabolism fibrosis crosstalk as a defining feature of HFpEF distinct from HFrEF

Heart failure with preserved ejection fraction (HFpEF) represents an entity distinct from heart failure with reduced ejection fraction (HFrEF), driven by highly heterogeneous and systemic pathophysiological mechanisms. Conventional biomarkers such as NT-proBNP primarily indicate hemodynamic stress and remain inad...

G. H. Nam, S. Kang, D. Cho · 0 citations
Open access Aug 2026

Association of Poor Adherence to Guideline-Directed Medical Treatment With Adverse Events Including Fatal Arrhythmia in Heart Failure With Reduced Ejection Fraction: A Nationwide Cohort Analysis.

BACKGROUND AND OBJECTIVES Poor adherence to guideline-directed medical therapy (GDMT) in heart failure with reduced ejection fraction (HFrEF) correlates with increased risks of mortality and hospitalization. Whether it is associated with life-threatening ventricular arrhythmias (VA) remains unclear. We assessed GDMT ad...

Moojun Kim, D. Cho, Ji-Mi Choi et al. · 0 citations

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