Open access
Aug 2026
Impact of IL-21 on CAR T-cell manufacturing: phenotypic, metabolic, and functional outcomes
Introduction Cytokines used during chimeric antigen receptor (CAR) T-cell manufacturing can influence product differentiation and functional fitness. Methods We investigated whether adding IL-21 to an IL-7 + IL-15 expansion regimen modulates CD84-directed CAR T cells (CART84) targeting CD84+ acute myeloid leukemia (AML...
Maria Val-Casals, Ane Altuna, L. Pérez-Amill et al.
· Frontiers in Immunology · 0 citations