OBJECTIVE
An increasingly compelling body of literature indicates that the glucocorticoid receptor cochaperone FK506-binding protein 51 (FKBP51; encoded by FKBP5) is a promising target for psychiatric therapeutics. Increased mRNA expression of FKBP5 in postmortem brains with psychiatric diagnoses and with aging have be...
K. Z. Edmond, Dominic Kaul, N. Yusupov et al.· American Journal of Psychiat...· 0 citations
PSD was associated with epigenetic signatures at birth, with a subset of associations persisting across early childhood and converging on cellular stress response biology, suggesting differential biological embedding of structural versus psychological dimensions of adversity.
Anna M. Constantino-Pettit, A. Lussier, Mia Ruppel et al.· bioRxiv· 0 citations
A high-resolution placental mQTL resource is constructed and systematically investigated how placental DNAm relates to early- and later-life traits, and to shared vulnerability and complex interactions among them.
A. Cilleros-Portet, Itziar González-Moro, Hachem Sadikki et al.· medRxiv· 0 citations
This work emphasizes the necessity of considering sex when investigating developmental and neurobiological underpinnings of stress-related disorders and displays a vast range of lasting effects of developmental stress on the brain, which provides a valuable resource for future studies aiming to improve psychiatric trea...
S. Narayan, C. Beer, V. Kovářová et al.· Proceedings of the National...· 0 citations
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