Author

D. D. de Souza

2 papers indexed here

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Review Open access Oct 2026

The Pesticide Pyrethroid Metabolite 3-Phenoxybenzoic Acid (3-PBA) Impairs Human Cardiac Nav1.5 and Action Potential Depolarization

This study demonstrates that 3-PBA interacts with human cardiac Nav1.5 expressed in Human Embryonic Kidney (HEK293) cells, and significantly increases INa-L in a concentration-dependent manner with an EC50 of 51.3 ± 5.1 µM, and suggests that its cardiotoxic potential may become clinically relevant under conditions of h...

Michael Ramon de Lima Conceição, L. Marques, Fabiana da Silva Alcântara et al. · Cardiovascular Toxicology · 0 citations

Open access Sep 2026

Connexin-43 remodeling drives atrial arrhythmias in hypothyroidism: ranolazine as a potential therapeutic strategy.

Hypothyroidism is associated with cardiovascular complications, including supraventricular arrhythmias. Thus, this study investigated functional and morphological alterations in the atrial of hypothyroid rats and evaluated the effects of acute ranolazine treatment on arrhythmia susceptibility. Hypothyroidism was induce...

Emanuel Barbosa dos Santos, Jonathan Ezequiel de Souza Bazilio, J. L. Teixeira-Fonseca et al. · Biochemical Pharmacology · 0 citations