Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
Bladder cancer is one of the most frequently observed cancer types globally. Urothelial bladder carcinoma (UBC) is the most common histologic subtype. Around 25% of patients present with muscle-invasive bladder cancer (MIBC) or metastatic disease, which are associated with poor prognosis. The PI3K/AKT/mTOR signaling pa...