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Open access Sep 2026

The activity, divergence, and evolutionary degradation of modern-day homing endonucleases and behavior of their reconstructed ancestors

Abstract Homing endonucleases (HEs) are selfish genetic elements that drive the mobilization of their own coding sequences, often in concert with surrounding introns. Homing endonuclease genes (HEGs) usually display life cycles in which they accumulate inactivating mutations after invading a host genomic target site, l...

Janet M. Young, A. Lambert, Janet M. Young et al. · 0 citations
Review Open access Sep 2026

An agentic AI environment to support biomedical research in collaborative academic environments

Agentic artificial intelligence (AAI) is increasingly used by biomedical scientists, where it has substantially lowered the difficulty of integrating computational, statistical and data-science approaches into day-to-day research activities, assisting with project design, analysis and manuscript preparation. Significan...

Timothy Wu, Tyler S. Browne, Mohamed Meawad et al. · 0 citations

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