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Author

D. Ehninger

2 papers indexed here

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Open access Aug 2026

Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation

Neural activity-dependent gene regulation is central to the development of neural networks and neuronal plasticity. Induction of activity-dependent gene programs is equally important as repression of these programs, and both need to be balanced carefully. However, little is known about how repressive mechanisms modulat...

Abhinav Soni, S. Petridi, Maria Ludovica Sforza et al. · 0 citations
Open access Aug 2026

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a histone chaperone and RTE repressor, is dow...

Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al. · 0 citations

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