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D. Gohara

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Open access May 2026

Recovery of proofreading-impaired SARS-CoV-2 reveals a mutator phenotype and an ExoN activity threshold for viability

This work indicates that SARS-CoV-2 can tolerate substantial impairment of proofreading but only when residual exonuclease activity remains above a minimal threshold, and defines this activity threshold to help guide antiviral strategies that target coronavirus proofreading.

Li He, Yuan-Wei Norman Su, Fushun Zhang et al. · 0 citations

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