Open access
Oct 2026
Carnitine acetyltransferase (CrAT)-Solute Carrier Family 25 Member 20 (SLC25A20) mediated acetylcarnitine shuttle links lipid oxidation to epigenetic control of cardiac metabolic maturation
During postnatal development, cardiomyocytes experience marked upregulation of lipid metabolism genes, which drives the transition from glycolysis to fatty acid β-oxidation (FAO). Fatty acids (FA) insufficiency hinders the maturation of induced pluripotent stem cell-derived cardiomyocytes, yet the underlying mech...
D. Guo, L. Hu, Y. Li
· European Heart Journal · 0 citations