WISP1 links WNT signaling, cytoskeletal remodeling, and metabolism to drive fibroblast-mediated fibrosis in CD, positioning WISP1 as a promising antifibrotic target.
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DIA- and Slice-PASEF show strong quantitative reproducibility, reduced ratio compression, and consistent species-abundance scaling, while functional profiling reveals expanded annotation depth, and the two highest-scoring methods, DIA- and Slice-PASEF, capture concordant host and microbial responses.
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