D. Holt

Blunted fear-evoked striatal dopamine release in individuals with a family history of psychosis

While excess tonic dopamine signalling is a hallmark of schizophrenia and psychotic disorders, it has been difficult to reconcile with dopamine-dependent learning deficits seen in schizophrenia. Excess spontaneous activity of tonic dopamine neurons, coupled with reduced coordinated activity of phasic dopamine neurons,...