Author

D. Holtzman

3 papers indexed here

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Open access Oct 2026

APOE2 attenuates APOE4-associated amyloid pathology and related toxicity in a mouse model of Alzheimer’s disease

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD), influencing amyloid-β (Aβ) aggregation, clearance, and glial function. While APOE4 promotes Aβ pathology and APOE2 is protective, how these opposing alleles interact in the heterozygous APOE2/4 state remains unknown. Her...

Kai Chen, Yi-Xing Chen, Ying-Xue Ren et al. · Nature Communications · 0 citations

Open access Oct 2026

APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction

Vascular-associated fibroblasts are a major source of pathogenic APOE4 that drives vascular dysfunction in cerebral amyloid angiopathy and are establish VAF-derived APOE4 as a compartment-specific driver of CAA and cerebrovascular dysfunction.

Fareeha Saadi, Yoonho Cho, Ilia V. Katritch et al. · bioRxiv · 0 citations

Open access Sep 2026

Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome.

There was no evidence of astrogliosis after microglia ablation as determined by proteome analysis and brain histology, crucial for interpreting changes to the CSF proteome in relation to neuroinflammatory changes in neurological diseases.

S. Büchner, Si-Hui Song, Stephan A. Müller et al. · Proteomics · 0 citations