Sep 2026
ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP.
BACKGROUND Immune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy. iTTP pathophysiology is based on severe ADAMTS13 deficiency caused by autoantibodies, leading to accumulation of ultra-large von Willebrand factor (VWF) multimers and microvascular thrombosis. Engineered ADAMT...
Yun-Peng Xue, M. Roest, S. J. Humphreys et al.
· Journal of Thrombosis and Ha... · 1 citation