David F. Kallmes

Risk of Hemorrhagic Transformation and Its Subtypes After Endovascular Therapy vs Medical Management in Large Core Ischemic Stroke: A Systematic Review and Meta Analysis of Randomized Clinical Trials.

BACKGROUND Endovascular therapy (EVT) improves outcomes in selected patients with large-core acute ischemic stroke (AIS), but concerns remain regarding hemorrhagic transformation (HT). We evaluated the risk of intracranial hemorrhage (ICH) and its subtypes following EVT versus medical management (MM). METHODS PubMed,...

Headache Outcomes After Flow Diversion or Coiling of Unruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis.

BACKGROUND Headache often prompts the imaging that reveals an unruptured intracranial aneurysm (UIA), but how endovascular treatment affects headache burden remains poorly defined. We pooled the incidence of de-novo and post-procedural headache and the rates of improvement and worsening, with treatment modality analyze...

Minocycline for neuroprotection in stroke and cerebral ischemia: a systematic review and meta-analysis.

Diagnostic Accuracy of Portable Low- and Ultra-Low-Field MRI for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Portable low/ultra-low-field MRI showed moderate diagnostic performance for AIS detection in comparative studies and may serve as a bedside adjunct where conventional MRI is constrained, however, given the false-negative risk, portable MRI should not be relied upon as a stand-alone rule-out test for AIS when clinical s...