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Open access Jul 2026

Baseline plasma C1q and C3 as potential biomarkers for lecanemab efficacy and ARIA risk in early Alzheimer's disease

Abstract INTRODUCTION The classical complement cascade has been implicated in amyloid beta (Aβ) clearance and in the pathogenesis of amyloid‐related imaging abnormalities (ARIA) during anti‐amyloid monoclonal antibody therapy. Clinically accessible peripheral biomarkers of this cascade remain uncharacterized in real‐wo...

Gihwan Byeon, Jung-Won Lee, Suhyung Kim et al. · 0 citations
Open access Sep 2026

748. Tau Pathology Modulates the Association Between Neurodegeneration and Depressive Symptoms in Alzheimer’s Disease

Abstract Background The moderating role of tau pathology in the association between neurodegeneration and depression across the Alzheimer’s disease continuum remains insufficiently characterized. Aims & Objectives This study aimed to examine whether tau pathology modifies the relationship between neurodegeneration mark...

J.-W. Lee, D. Kang · 0 citations

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