Open access
Sep 2026
Structure based discovery of antipsychotic-like TAAR1 agonists
Schizophrenia is a severe mental illness whose current treatments primarily target dopamine and serotonin receptors. These drugs often cause side effects and vary in effectiveness across patients. The trace amine-associated receptor 1 (TAAR1), which modulates monoamine signaling, has emerged as a promising alternativ...
Si-Jie Huang, Heng Liu, Yu-Jin Wu et al.
· Nature Communications · 0 citations