Amyloid-Independent Elevation of Plasma phosphorylated tau-217 Tracks Neurodegenerative Risk in Tuberous Sclerosis Complex: Implications for mTOR-Targeted Intervention
A novel link between TSC and AD that substantiates shared downstream neurodegenerative pathways is suggested and the potential utility of ptau-217 as a minimally invasive biomarker for TAND severity, neurodegenerative risk, and AD-like prognosis in TSC is supported and as a tool to guide new mTOR-targeted therapeutic s...