Rational design of imidazolium-functionalized liposomes for mitochondrial delivery: From amphiphile architecture to organelle-specific targeting.
Mitochondria are attractive targets for anticancer therapy because of their central role in cellular metabolism and apoptosis. Here, we report a series of hydroxypropyl-functionalized imidazolium surfactants (HPIm-n, n = 12, 14, 16, and 18) and their use as non-covalent modifiers of liposomal nanocarriers. The surfacta...