Open access
Sep 2026
Promiscuous Metal Site in Hepatitis B Virus X Protein Binds an Fe-S Cluster.
Fe-S clusters are emerging as important cofactors in viral replication but are frequently misassigned as Zn due to their O2-sensitivity and overlapping cysteine-based coordination chemistry. The Hepatitis B virus regulatory protein HBx, which is essential for viral replication and hepatocarcinogenesis, has long remaine...
Jia-Hua Chen, Michelle Langton, P. Cao et al.
· ACS Chemical Biology · 0 citations