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Author

D. Lafontaine

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2 papers indexed here

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Open access Sep 2026

Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation

The results define a stepwise framework for nuclear reorganization during human embryonic stem cell differentiation and reveal that the transition from pluripotency to a differentiated state proceeds through coordinated, temporally ordered structural events.

Xiangru Huo, D. Lafontaine, Thomas Reimonn et al. · 0 citations
Open access Aug 2026

Formation of an RNA-mediated nuclear compartment

Mammalian nuclei are spatially compartmentalized so that active and inactive segments of the genome occupy separate sub-nuclear neighborhoods. Compartments are often found in association with nuclear structures such as the nuclear lamina, nucleoli, and nuclear speckles (speckles), suggesting links between them. The mol...

D. Lafontaine, Ezequiel Calvo-Roitberg, Yu-Chieh Chung et al. · 0 citations

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