Author

Diether Lambrechts

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Open access Oct 2026

Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities.

Microsatellite-stable (MSS) colorectal cancer (CRC) is a molecularly complex and clinically challenging disease subtype, lacking effective targeted therapies. Leveraging multiomic data from ∼2,000 tumor samples (including 316MSS CRCs not previously profiled) representing ∼4,500 molecular profiles and 195,246 single cel...

A. Sadanandam, A. O'Farrell, I. Miller et al. · Cancer Cell · 1 citation

Sep 2026

Pre-existing immunity and hrHPV status determine immunotherapy response in advanced penile cancer: biomarkers and overall survival in the PERICLES trial.

Mature overall survival (OS) and updated progression-free survival (PFS) outcomes and an in-depth biomarker analysis are reported and highlighted CD8+PD1+ T-cells as candidate biomarkers in relation to clinical benefit from immune checkpoint blockade in advanced PeSCC.

T. Rafael, Alberto Gil-Jimenez, L. Elst et al. · Cancer immunology research · 0 citations