Author

D. Langenau

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Review Open access Sep 2026

Zebrafish against cancer: towards clinical relevance.

Most cancer therapeutics that show preclinical promise fail in clinical trials, underscoring the need for complementary disease models. Over the past two decades, zebrafish models have matured from a tool for studying vertebrate development into a versatile platform spanning the translational cancer pipeline. Transgeni...

Gabriel Forn-Cuní, Bruno Lopes-Bastos, D. Langenau et al. · Disease Models & Mechanisms · 0 citations

Sep 2026

Abstract A024: Cell state regulation of metastasis in Fusion-negative Rhabdomyosarcoma

Fusion-negative Rhabdomyosarcoma (FN-RMS) is a common childhood soft tissue sarcoma with hundreds of cases diagnosed annually in the United States. Despite having good treatment outcomes in the primary tumor setting, metastatic RMS has an abysmal prognosis with less than 20% of patients surviving the disease. Thus, t...

Jihee Lee, M. Bakr, D. Kannambadi et al. · Cancer Research · 0 citations

Sep 2026

Abstract A016: Polyploid giant cancer cells secrete Interferon-beta to induce chemoresistant cell states in fusion-negative rhabdomyosarcoma

Fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood muscle cancer where relapse and refractory disease lead to poor outcomes. Our group has recently shown that FN-RMS is a cancer stem cell (CSC) disease and that these CD44+/CD90+/EGFR+ cells likely contribute to therapy-resistance, yet the precise mechanisms gov...

S. Mathavarajah, Tiffany C. Y. Eng, Elisa J. Quantin et al. · Cancer Research · 0 citations