Frequent nightmares affect roughly 2-6% of the population and may reflect underlying psychopathology, such as post-traumatic stress disorder (PTSD), or, when recurrent and distressing, be diagnosed as nightmare disorder (ND). The genetic basis of nightmares remains poorly understood. We performed a genome-wide associat...
J. Gelernter, J. Hirsch, C. Overstreet et al.· medRxiv· 0 citations
Summary Paragraph Personality traits describe stable differences in how people think, feel, and behave and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, generalizability,...
T. Schwaba, Margaret L. Clapp Sullivan, W. Akingbuwa et al.· Nature· 5 citations· ⚡1
BACKGROUND
Bipolar disorder (BD) studies consistently implicate the ventral prefrontal cortex (VPFC) in association with suicidal behaviors. A suicidal behavior polygenic risk score (PRS) can now be computed to test whether elevated genetic risk for suicidal behavior is associated with variation in VPFC gray matter and...
Noa Katz Shroitman, D. Levey, Brian P. Pittman et al.· Bipolar Disorders· 0 citations
Regression analyses showed that PTSD case status was significantly associated with accelerated DNA methylation aging, and smoking status stratification suggested that the association between PTSD and methylation of the AHRR gene may be confounded by smoking status.
Sarah Beck, D. Levey, M. Galimberti et al.· medRxiv· 0 citations
In both AFR and EUR, environmental factors explained most of the variance in AUD criterion count, but polygenic risk was also a statistically significant predictor, and the pattern of results for OUD was similar.
P. Na, J. Deak, D. Levey et al.· International Journal of Neu...· 0 citations
These findings expand the known genetic architecture of migraine across ancestries and provide a genetics-led map connecting association signals with biological pathways, multimorbidity and candidate therapeutic mechanisms, providing a foundation for future functional and translational studies.
C. Overstreet, M. Galimberti, K. Harsan et al.· medRxiv· 0 citations
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