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Open access Aug 2026

A New Paradigm for Clostridioides difficile Infection: Atypical Presentations Correlating to Acute Gastrointestinal Dysmotility Are Associated With Increased Mortality.

BACKGROUND Damage to the enteric nervous system in murine Clostridioides difficile infection (CDI) has recently been postulated as an explanation for the paradoxical dysmotility, including ileus, observed in a disease generally characterized by diarrheal onset. However, the clinical spectrum and mortality implications...

E. Bishop, Steven J. Mileto, T. Ravipati et al. · 0 citations
Review Open access Sep 2026

Virulence on the move: toxin plasmids drive diversity and disease in Clostridium perfringens

Advances in the understanding of toxin diversity and plasmid biology in C. perfringens are reviewed, highlighting the remarkable plasticity of its mobile genome and positioning C. perfringens as a compelling model to understand how mobile genetic elements drive virulence, adaptation and disease in bacterial pathogens.

Sarah A. Revitt-Mills, D. Lyras · 1 citation

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