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D. Marenduzzo

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Preprint Oct 2026

Design Principles for Programmable Topological Soft Networks

Physical crosslinks in conventional gels are static and spatially localised, fundamentally limiting their capacity to adapt, self-heal, or perform mechanical work. Topological gels, which are held together by physical entanglements such as threadings, links, and mechanical interlocks, constitute a different paradigm by...

A. Bonato, D. Marenduzzo, E. Orlandini · 0 citations
Preprint Aug 2026

Topological Signatures of Hardness and Structural Order in Network-Forming Materials

Understanding how the topology of network forming materials influences their physical properties remains a longstanding challenge. Here, we investigate the topology of experimentally compatible atomistic models of amorphous silica together with the crystalline polymorphs cristobalite and quartz. By comparing multiple a...

Y. G. Fosado, A. Daramola, D. Marenduzzo et al. · 0 citations
Open access Aug 2026

Irregular nucleosome positioning governs a crystalline to liquid-like phase transition and tunes chromatin accessibility

Using synthetic chromatin fibres assembled from physiologically relevant DNA sequences, it is shown that nucleosome positioning dictates the material state of chromatin, indicating that nucleosome positioning tunes chromatin toward or away from critical structural states that couple genome protection, chromatin dynamic...

Waad Albawardi, Matthew Thomas, Gert-Jan Kuijntjes et al. · 0 citations
Open access Aug 2026

Cross-chemistry single-nucleus RNA-seq identifies gene length and CpG-island promoters as determinants of transcriptional noise

Cell-to-cell transcriptional heterogeneity, or noise, is an intrinsic property of the transcriptome with implications for development, disease progression, and aging. Bulk RNA-seq masks this variability by averaging gene expression across cells, whereas single-cell RNA sequencing (scRNA-seq) resolves it. Nevertheless,...

Rafal Czapiewski, M. Chiang, James Ding et al. · 0 citations

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