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D. N. Raju

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2 papers indexed here

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Preprint Oct 2026

TIRA: Tumor Immune Representation Adaptation for Zero-Shot Cross-Cancer MSI and TMB Prediction

Microsatellite instability-high (MSI-H) and high tumor mutational burden (TMB-H) are clinically relevant biomarkers, yet their histopathological prediction remains challenging when models are transferred across morphologically distinct cancer types. Immune-associated spatial patterns can persist across cancers despite...

D. N. Raju · 0 citations
Preprint Sep 2026

Conserved Immune Topology Improves Pathology Foundation Model Generalization for Cross-Cancer MSI-H Prediction

The proposed Conserved Immune Topology (CIT) is a lightweight spatial representation for cross-cancer MSI-H prediction that augments foundation-model embeddings with biologically motivated immune descriptors, supporting cross-cancer generalization of pathology foundation models.

D. N. Raju · 0 citations

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