Review
Open access
Aug 2026
Mechanistic Insights into the Hypoxia-Inducible Factor-1 Paradox in Alzheimer’s Disease: A Double-Edged Sword in Neurodegeneration
Background/Objectives: Alzheimer’s disease (AD), one of the most prevalent neurodegenerative disorders in the elderly, is characterized by progressive cognitive loss, amyloid-β (Aβ) plaque deposition, and neurofibrillary tangle formation. Cerebral hypoxia has been reported as a complex modulator of AD pathology, with h...
Asma Aktar, N. Ferdiousi, Md. Minhazur Rahman et al.
· The biochemist · 0 citations