Glycan recognition by DC-SIGN, Galectins, and Siglecs: structural insights and ligand-based drug design strategies- a review.
Glycan-mediated communication between immune cells and their environment is orchestrated by a structurally diverse set of lectin receptors whose exquisite ligand specificity governs both protective immunity and pathological immune evasion. Among these, the C-type lectin DC-SIGN, the proto- and chimera-type Galectins, a...