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Author

D. Pascall

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Open access Jul 2026

Complex intra-host SARS-CoV-2 evolution following monoclonal antibody pre-exposure prophylaxis

Sotrovimab pre-exposure prophylaxis in an immunocompromised patient did not prevent SARS-CoV-2 infection, and was selected for resistant mutation E340D, with unexpected fitness consequences across non-receptor binding domain spike regions.

K. Kamelian, D. Pascall, Mei-Jun Cheng et al. · 1 citation
Jul 2026

Complex intra-host SARS-CoV-2 evolution following monoclonal antibody pre-exposure prophylaxis 2309595

Fixation of E340D abolished the surrogate defence provided by sotrovimab, eliminating neutralizing activity and exerting a positive epistatic effect on emerging mutations, which conferred the highest infectivity across all cell lines, with the most significant effect in low-TMPRSS2 cells.

K. Kamelian, D. Pascall, M. Cheng et al. · 0 citations

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