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Open access Jul 2026

Integrative Modeling of Read Depth and B-Allele Frequency Improves Single-Cell Copy Number Calling from Targeted DNA Sequencing Panels

Copy number variations (CNVs) drive cancer initiation and progression, but resolving them at single-cell resolution from targeted DNA sequencing panels remains challenging. The Mission Bio Tapestri platform generates 2 complementary signals for CNV inference: sequencing depth and B-allele frequency (BAF) from heterozyg...

D. Pei, Rachel Griffard-Smith, Brahian Cano Urrego et al. · 0 citations

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