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D. Perkins

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Sep 2026

Epigenetic C-reactive protein and corticolimbic gray matter volume in youth at clinical high risk for psychosis.

AIMS Inflammation and structural brain alterations are implicated in psychosis risk, yet it remains unknown whether epigenetic C-reactive protein (CRP), a DNA methylation-based estimator of cumulative inflammatory burden, is associated with brain structure in youth at clinical high risk for psychosis (CHR-P). METHODS...

B. Ku, Ying Xu, David R. Goldsmith et al. · 0 citations
Open access Oct 2026

Prospective Bidirectional Associations Between Core Schemas, Attenuated Psychotic Symptoms, and Functioning in Youth at Clinical High Risk for Psychosis

Objective: Cognitive models of psychosis implicate maladaptive core schemas in the development and emergence of psychotic symptoms, but no study has tested temporal dynamics between schemas and psychotic symptoms in a large sample of clinical high-risk (CHR) youth. Given their sizable role in cognitive behavioral thera...

A. Broekhuijse, A. Saxena, C. Mourgues-Codern et al. · 0 citations
Open access Sep 2026

Unraveling Suicidal Ideation and Behaviors in a Global Cohort of Individuals at Clinical High-Risk for Psychosis: Multivariable Correlates and Subthreshold Psychotic Symptoms.

SIB in CHR-P individuals reflects a multidimensional clinical profile primarily outside of core psychosis-risk symptoms, and overall subthreshold psychotic symptoms across the SIB spectrum indicate increasing overall subthreshold psychotic symptoms across the SIB spectrum.

S. Damiani, M. Orlandi, U. Provenzani et al. · 0 citations
Open access Sep 2026

711. Brain-Derived Exosomal MicroRNAs Predict Psychosis Onset in Clinical High-Risk Individuals: Externally Validated

This study provides the first externally validated evidence that circulating brain-derived exosomal-miRNAs regulating redox pathways can predict psychosis onset in CHR with high accuracy and suggests that redox dysregulation may represent a therapeutic target for psychosis prevention.

I. Khadimallah, K. Do, D. Oliver et al. · 0 citations
Open access Jul 2026

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis

A relationship between sleep disturbance and suicidal ideation/attempts in CHR is supported, with participants who had lifetime ideation and attempts experiencing more sleep disturbance than those with no ideation or attempts.

H. Wastler, Aubrey M. Moe, Alexandra M Blouin et al. · 0 citations
Open access Aug 2026

Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity

Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present study examines structure–function relationships—spe...

K. Aberizk, B. Ku, Heng-Yi Cao et al. · 0 citations

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