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D. Polatova

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Open access Sep 2026

FOXM1 as a candidate dosage rheostat and state selector in breast cancer: linking multilevel regulation to adaptive plasticity and therapy resistance

FOXM1, a forkhead-box transcription factor, is consistently overexpressed in breast cancer, particularly in the basal-like and triple-negative subtypes, in which high expression predicts poor survival. We propose, as a falsifiable hypothesis rather than an established mechanism, that FOXM1 may function as a dosage-inte...

G. Oriquat, Hani Moslem Ahmed, J. Rizaev et al. · 0 citations
Review Oct 2026

Engineering smart polymeric lipid nanoparticles for breast cancer: The convergence of AI and medical personalization to enhance efficacy and safety.

Breast Cancer (BC) continues to be a predominant cause of cancer-related death globally, with clinical therapy impeded by off-target toxicity and limited therapeutic windows of traditional chemotherapeutics, especially across various molecular subtypes. This study critically assesses the integration of advanced nanocar...

Usamah Sayed, Diyora Azamova, A. Abdulqader et al. · 0 citations
Review Open access Sep 2026

Viral exploitation of p300/CBP at the virus-cancer interface: Chromatin regulation, oncogenesis, immune evasion, and therapeutic targeting.

The transcriptional coactivators p300 and CREB-binding protein (CBP) integrate chromatin remodeling, enhancer activity, lysine acetylation, immune signaling, and tumor-suppressor control, making them recurrent targets of viral proteins. This narrative review examines p300/CBP at the virus-cancer interface, prioritizing...

A. Atoom, J. Rizaev, D. Polatova et al. · 0 citations
Review Open access Sep 2026

Oncolytic virotherapy at the tumor microenvironment-CAR Therapy interface: Mechanisms, clinical translation, and future directions.

Oncolytic virotherapy has evolved from a tumor-selective cytolytic strategy into a programmable immunotherapeutic platform that reshapes the tumor microenvironment (TME). Oncolytic viruses (OVs) selectively infect malignant cells, induce immunogenic cell death, release tumor antigens, and activate innate and adaptive i...

A. Atoom, J. Rizaev, D. Polatova et al. · 0 citations
Review Open access Sep 2026

Oncostatin M as a Multifunctional Regulator of Breast Cancer Progression: Current Insights and Future Therapeutic Avenues

This review aims to examine the emerging roles of OSM in BC, elucidate its multifunctional role in tumor regulation and progression, and ultimately explore therapeutic strategies developed to modulate this cytokine in the context of BC.

Muslem Nuseir, Farrukh Ismatov, A. Abdulqader et al. · 0 citations

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