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Aug 2026

Optimized Lamotrigine-Loaded Polymeric Nanoparticles for Enhanced Drug Delivery: A Box-Behnken Design Approach with Integrated In Vivo Evaluation

The clinical utility of lamotrigine in epilepsy is limited by poor aqueous solubility, variable oral absorption, short half-life, and P-glycoprotein-mediated efflux at the blood-brain barrier. This study aimed to develop an optimized chitosan-sodium alginate polymeric nanoparticle system for Lamotrigine with desire...

D. R, J. B., K. M et al. · 0 citations

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