Aims Cardiac arrhythmias are a major cause of morbidity and sudden cardiac death worldwide, and hypothyroidism has emerged as an important risk factor. Among the mechanisms involved in cardiac electrical stability, nitric oxide (NO) signaling, particularly via endothelial nitric oxide synthase (eNOS), plays a critical...
D. S. Souza, L. Marques, A. Durço et al.· Redox Biology· 0 citations
This study demonstrates that 3-PBA interacts with human cardiac Nav1.5 expressed in Human Embryonic Kidney (HEK293) cells, and significantly increases INa-L in a concentration-dependent manner with an EC50 of 51.3 ± 5.1 µM, and suggests that its cardiotoxic potential may become clinically relevant under conditions of h...
Michael Ramon de Lima Conceição, L. Marques, Fabiana da Silva Alcântara et al.· Cardiovascular Toxicology· 0 citations
Hypothyroidism is associated with cardiovascular complications, including supraventricular arrhythmias. Thus, this study investigated functional and morphological alterations in the atrial of hypothyroid rats and evaluated the effects of acute ranolazine treatment on arrhythmia susceptibility. Hypothyroidism was induce...
Emanuel Barbosa dos Santos, Jonathan Ezequiel de Souza Bazilio, J. L. Teixeira-Fonseca et al.· Biochemical Pharmacology· 0 citations
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